Body Protection Compound · Pentadecapeptide · 15 Amino Acids
A naturally occurring gastric peptide demonstrating remarkable regenerative properties across musculoskeletal, gastrointestinal and neurological tissue in preclinical research spanning over three decades.
BPC-157 is a synthetic peptide consisting of 15 amino acids derived from a protein found in human gastric juice, first isolated and studied by Dr. Predrag Sikiric at the University of Zagreb in 1993. It is one of the most extensively studied healing peptides with over 36 published studies spanning musculoskeletal repair, gut health, neurological protection and cardiovascular effects.
BPC-157 works through several parallel mechanisms: upregulation of growth factors including VEGFR2 promoting angiogenesis at injury sites; acceleration of fibroblast migration and tendon outgrowth; reduction of pro-inflammatory cytokines; nitric oxide pathway modulation; and cytoprotective maintenance of the gastrointestinal mucosal lining.
A 2025 systematic review covering 36 studies (1993–2024) found consistent evidence of improved healing in muscle, tendon, ligament and bone injury models. In the most significant human retrospective study, 14 of 16 patients with chronic knee pain reported significant relief following intraarticular injection — an 87.5% positive response rate. Results in animal models consistently show healing without scar tissue formation.
Originally isolated from gastric juice, BPC-157's GI protective effects are well-documented — protecting against and healing gastric ulcers, colitis and NSAID-induced gut damage. Its ability to maintain mucosal integrity makes it particularly relevant for gut permeability conditions.
Across all animal studies BPC-157 has demonstrated a clean safety profile with no toxic effects reported. In the three completed human studies no adverse effects were reported. Formal Phase I human safety trials have not been completed as of 2024.